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Latest from Actorius

Explore the latest updates, research perspectives, announcements, and stories shaping our work.

ASCO 2024 | Actorius Innovations and Research
3 June 2024
Publications

ASCO 2024: Association of complementing ctDNA and CTCs load on stable and progressive disease in treated patients.

Complementary ctDNA and CTC biomarkers reveal minimal residual disease and predict cancer progression after curative-intent treatment.

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Nature India | Actorius Innovations and Research
11 April 2024
Press Release

Magnetic nanocrystals capture tumour cells from blood samples

These nanomaterials could speed up discovery of anti-cancer drugs

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AACR 2024 | Actorius Innovations and Research
10 April 2024
Publications

AACR 2024: Distribution prophecy of circulating tumor cell clusters in CTC populace patients of epithelial cancers

Large-scale analysis of circulating tumor cells and clusters reveals their role in predicting aggressive epithelial cancers and treatment resistance.

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AACR 2024 | Actorius Innovations and Research
10 April 2024
Publications

AACR 2024: Evaluation of HER-2 expression on circulating tumor cells as a real time biomarker in advanced breast cancer

HER2 analysis on circulating tumor cells using the OncoDiscover® platform enables real-time, non-invasive profiling for improved metastatic breast cancer treatment decisions.

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CTC together with Shh and Nrf2 are prospective diagnostic markers for HNSCC
4 April 2024
Manuscript

Manuscript: CTC together with Shh and Nrf2 are prospective diagnostic markers for HNSCC

Study links Shh/Nrf2 overexpression with circulating tumor cells in HNSCC, highlighting their potential as biomarkers for early detection and survival prediction.

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ESMO 2023 | Actorius Innovations and Research
24 October 2023
Publications

ESMO 2023: Expression of PD-L1 and EGFR on circulating tumor cells in advanced Lung cancer patients

CTC analysis using OncoDiscover® enables dynamic detection of PD-L1 and EGFR targets in advanced lung cancer, supporting personalized targeted and immunotherapy decisions.

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Magnetically activated nanocellulose enables efficient CTC capture in head & neck cancer.
20 September 2023
Manuscript

Manuscript: Magnetically-activated, nanostructured cellulose for efficient capture of CTCs from the blood sample of head and neck cancer patients

Study compares CNC and CNF cellulose nanostructures for EpCAM-based CTC capture in head and neck cancer, enabling affordable real-time cancer monitoring.

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CTCs in recurrent and metastatic head & neck squamous cell carcinoma.
20 July 2023
Manuscript

Manuscript: Role of circulating tumour cells (CTCs) in recurrent/metastatic head and neck squamous cell carcinoma (HNSCC)

This study highlights the utility of CTCs as a disease progression monitoring tool in recurrent HNSCC patients. Our findings suggest the potential clinical utility of CTCs and the need for further exploration in upfront settings of the disease as well (NCT: CTRL/2020/02/023378).

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ASCO 2023 | Actorius Innovations and Research
6 June 2023
Publications

ASCO 2023: Effect of circulating tumor cells distribution in treatment naive and treated patients with advance stage breast cancer on disease burden.

A study of 417 breast cancer patients shows tracking circulating tumor cells (CTCs) effectively monitors therapy response and recurrence risk.

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ASCO 2023 | Actorius Innovations and Research
6 June 2023
Publications

ASCO 2023: Circulating tumor cells (CTCs) detection and isolation in different subtypes of early-stage breast cancer patients from Bangladesh.

A trial found CTCs in 60% of early-stage breast cancer patients, notably all HER2-positive cases, linking them to tumor grade. Send the next!

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AACR 2023 | Actorius Innovations and Research
19 April 2023
Publications

AACR 2023: Detection of PD-L1, HER2 and EGFR on circulating tumor cells in carcinoma patients.

CTC analysis in 134 patients successfully detected PD-L1, HER2, and EGFR, proving its value as a real-time guide for targeted therapies.

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Chemical tunability of advanced materials used in the fabrication of micro/nanobots
11 April 2023
Manuscript

Manuscript: Chemical tunability of advanced materials used in the fabrication of micro/nanobots

Review on chemically tunable micro- and nanobots for targeted nanomedicine, highlighting AI materials, applications, and biosafety considerations.

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Economic times  | Actorius Innovations and Research
6 March 2023
Press Release

Pune start-up gets US patent for delivering drugs to site-specific organs

The patent was granted to Actorius Innovations and Research and its team that designed capsule shells using natural polymer to obtain a delayed release profile suitable for delivery of drugs to colon and rectum, said Dr Jayant Khandare, founder-director and Chief Scientific Officer of the start-up.

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AACR 2023 | Actorius Innovations and Research
15 January 2023
Publications

AACR 2023: Abstract PR007: Comprehensive ctDNA profiling reveals potential metastatic genomic signatures in treatment-naive early-stage breast cancer patients

Comprehensive ctDNA profiling and CTC analysis in early-stage breast cancer identifies driver mutations to predict early metastasis.

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Dr. Jayant Khandare interview with Metro News Gujarat
9 August 2022
Press Release

Revolutionary OncoDiscover® Blood Test for Early Cancer Detection - Metro News Gujarat

Dr. Jayant Khandare interview with Metro News Gujarat

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Preoperative CTC levels predict prognosis and survival in oral squamous cell carcinoma.
1 July 2022
Manuscript

Manuscript: Circulating tumor cells as a predictor for poor prognostic factors and overall survival in treatment nay¨ve oral squamous cell carcinoma patients

Preoperative circulating tumor cell levels strongly correlate with metastasis, disease severity, and reduced survival in oral squamous cell carcinoma patients.

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ASCO 2022 | Actorius Innovations and Research
7 June 2022
Publications

ASCO 2022: CTCs as a biomarker for monitoring: Disease progression, treatment response, and minimal residual disease.

Study of 127 patients shows CTCs are a dynamic biomarker for monitoring disease progression and therapy response in advanced epithelial cancers.

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ASCO. 2022 | Actorius Innovations and Research
7 June 2022
Publications

ASCO 2022: Machine learning (ML)–enabled, circulating tumor cell–based classification of patients for non-prerequisite adjuvant therapy.

An XGBoost ML model using CTCs and clinical data achieved 84% accuracy in predicting the need for adjuvant therapy in 380 HNSCC patients.

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ASCO 2022 | Actorius Innovations and Research
7 June 2022
Publications

ASCO 2022: Extracorporeal microchannel device to capture and eliminate circulating tumor cells from
cancer patient’s blood.

A 3D-printed G-EpCAM device successfully captured over 85% of CTCs with minimal hemolysis, offering a new way to stem metastatic progression.

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ASCO 2022 | Actorius Innovations and Research
7 June 2022
Publications

ASCO 2022: A feasibility study of EMF (erlotinib+methotrexate+5-fluorouracil) regimen in recurrent HNSCC and role of CTCs in assessment of outcomes.

A phase II trial shows EMF triplet therapy is a safe, effective option for HNSCC, with CTCs serving as a promising biomarker for therapy response.

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A set of diagnostics will be run on the patient’s blood sample and the report shall be provided in 7 working days upon receipt of sample on site.

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